Metabolomics Services

Cannabis-based products can differ in their composition (including bioactive compounds) depending on the processing practices, even if the starting material is homogeneous or standardized. Through ICCI Metabolomics services you will be able to analyze various types of plants, extracts, oils, and other cannabis-based products. Our service offers several approaches in the metabolomic analysis fit-for-purpose of your samples and individual needs:

Metabolomic profiling / fingerprinting

Metabolomic profiling / fingerprinting is based on the non-selective determination of all of the low molecular organic compounds ionizable and detectable using the particular instrumental technique equipped with the high-resolution mass spectrometry analyzers, that is utilized according the sample type and the customer needs (the combination of various techniques is also possible).

  • Direct Analysis in Real Time (DART) coupled with High Resolution Mass Spectrometry (HRMS)

  • Ultra High Performance Liquid Chromatography (U-HPLC) coupled with Tandem High Resolution Mass Spectrometry (HR MS/MS)

  • Gas Chromatography (GC) coupled with Tandem High Resolution Mass Spectrometry (HR MS/MS)

  • Supercritical Fluid Chromatography (SFC) coupled with Tandem High Resolution Mass Spectrometry (HR MS/MS)

What are the main benefits achievable by HRMS? High accuracy, high specificity, low limits of detection or quantification, and identification of effect (bio)markers.

The discoveries utilize metabolomic analysis as a break-through technology, which when applied to cannabis brings higher resolution for identification and characterization of the product.

Phytocannabinoids and other bioactive compounds target screening/profiling

The unique internal database of over 240 phytocannabinoids and 150 of other bioactive compounds (e.g. flavonoids, phenols, terpenoids, amides, fatty acids, phytosterols, spermidine alkaloids) and utilization of the U-HPLC–HRMS/MS technique enables to determine the profile of an entire set of present phytocannabinoids, including also the minor ones, and also the profile of the other bioactive compounds that might have a significant influence on the biological effects of the cannabis plant and cannabis-based products.

Profile of phytocannabinoids (in green) and other bioactive compounds (in red) detected in four different cannabis extracts (the resulting output is accompanied with the detailed list of the detected compounds and their characteristics):

Library of metabolomics

ICCI has built a unique biological library of cultivar's and whole plant product's metabolomics that characterize and catalogue the full spectrum of compounds (known and unknown) from each analysed cannabis matrix. This library is a unique tool for matching metabolomics profiles with desired indications for optimal clinical trial design, recommendations for personalized treatment methods and agricultural sciences.

Metabolomic tools

The examples of the metabolomics services application areas:

  • Identifying new compounds with unique structures and / or therapeutic effects

  • Matching metabolomics profiles with desired indications for optimal clinical trial design

  • Plant breeding and quality evaluations

  • Plant’s metabolic changes in response to environmental circumstances

  • Comparison of the total metabolites, phytocannabinoids and other bioactive compounds profiles between various cannabis varieties and chemotypes or different plant parts (flowers, seeds, leaves, stem, roots)

  • Identifying the best extraction procedure and conditions providing the high yield of phytocannabinoids and other desired compounds

  • Documentation of the metabolite changes after heat exposure

  • Authentication of the cannabis plants or products

  • Standardization of the cannabis plants, products or production technology (batch-to-batch comparison) in a variety of health care branches

  • Better preparedness to enter markets where medical cannabis is a subject to strict regulation



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